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Disorders of Sex Development - Health Encyclopedia - University

Double uterus Mayo Clinic, Published September 11, 2010 a b "An Interview with. A repeat elevated serum value exceeding 500 ng/dL at this point makes the diagnosis highly likely. Atypical genitalia can be a difficult experience for families. Females have two X chromosomes, and males have one X and one Y chromosome.

Despite a 46,XY karyotype and gonads with the typical appearance of testes (perhaps altered similarly to those with cryptorchidism a feminine gender assignment is unquestionable because of the completely feminine phenotype and because end-organ failure prevents endocrinologically produced masculinization. Genetic counseling is important.

18 Micropenis may be the result of undervirilization during fetal development or may be caused by an underlying intersex condition, such as mild androgen insensitivity syndrome, partial androgen insensitivity syndrome, or Klinefelter syndrome. If the uterus remains in place, remember that unopposed estrogen can increase incidence of endometrial carcinoma; thus, these patients must be cycled with a combination of estrogen and a progestational agent.